您目前所在的位置:首页 - 期刊简介 - 详细页面

铁道科学与工程学报

JOURNAL OF RAILWAY SCIENCE AND ENGINEERING

Vol. 18    No. 5    October 2008

[PDF Download]    

    

Preparation of poly-L-lactide/bioactive glass composite and evaluation of cytotoxicity in vitro
ZHOU Zhi-hua(周智华)1, 2, RUAN Jian-ming(阮建明)1, ZOU Jian-peng(邹俭鹏)1,
ZHOU Zhong-cheng(周忠诚)1, CHEN Liang-long(陈良龙)3

1. State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China;
2. College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China;
3. Department of Orthopedics, the Second Xiangya Hospital, Central South University, Changsha 410011, China

Abstract:Bioactive and bioresorbable composite materials were fabricated from poly-L-lactide and bioactive glass (average particle size 6.8 μm) by a solvent evaporation technique. Cellular cultivation in vitro and MTT assay were conducted for evaluating the influence on morphology, growth and proliferation of cultured fibroblasts. The results of cytotoxicity testing show that cells cultured in extracts of PLLA/BG and on the surface of composites demonstrate normal growth and proliferation. The bioactive glass in PLLA composite facilitates both adhesion and proliferation of rat fibroblasts on PLLA/bioactive glass composite film.

 

Key words: poly-L-lactide; bioactive glass; composite; cytotoxicity; biocompatibility; in vitro

ISSN 1672-7029
CN 43-1423/U

主管:中华人民共和国教育部 主办:中南大学 中国铁道学会 承办:中南大学
湘ICP备09001153号 版权所有:《铁道科学与工程学报》编辑部
------------------------------------------------------------------------------------------
地 址:湖南省长沙市韶山南路22号 邮编:410075
电 话:0731-82655133,82656174   传真:0731-82655133   电子邮箱:jrse@mail.csu.edu.cn